The literature on deep brain stimulation (DBS) and adaptive DBS (aDBS) raises concerns that these technologies may affect personality, mood, and behavior. We conducted semi-structured interviews with researchers (n = 23) involved in developing next-generation DBS systems, exploring their perspectives on ethics and policy topics including whether DBS/aDBS can cause such changes. The majority of researchers reported being aware of personality, mood, or behavioral (PMB) changes in recipients of DBS/aDBS. Researchers offered varying estimates of the frequency of PMB changes. A (...) smaller majority reported changes in personality specifically. Some expressed reservations about the scientific status of the term ‘personality,’ while others used it freely. Most researchers discussed negative PMB changes, but a majority said that DBS/aDBS can also result in positive changes. Several researchers viewed positive PMB changes as part of the therapeutic goal in psychiatric applications of DBS/aDBS. Finally, several discussed potential causes of PMB changes other than the device itself. (shrink)

The expansion of research on deep brain stimulation (DBS) and adaptive DBS (aDBS) raises important neuroethics and policy questions related to data sharing. However, there has been little empirical research on the perspectives of experts developing these technologies. We conducted semi-structured, open-ended interviews with aDBS researchers regarding their data sharing practices and their perspectives on ethical and policy issues related to sharing. Researchers expressed support for and a commitment to sharing, with most saying that they were either sharing their data (...) or would share in the future and that doing so was important for advancing the field. However, those who are sharing reported a variety of sharing partners, suggesting heterogeneity in sharing practices and lack of the broad sharing that would reflect principles of open science. Researchers described several concerns and barriers related to sharing, including privacy and confidentiality, the usability of shared data by others, ownership and control of data (including potential commercialization), and limited resources for sharing. They also suggested potential solutions to these challenges, including additional safeguards to address privacy issues, standardization and transparency in analysis to address issues of data usability, professional norms and heightened cooperation to address issues of ownership and control, and streamlining of data transmission to address resource limitations. Researchers also offered a range of views on the sensitivity of neural activity data (NAD) and data related to mental health in the context of sharing. These findings are an important input to deliberations by researchers, policymakers, neuroethicists, and other stakeholders as they navigate ethics and policy questions related to aDBS research. (shrink)

The capacity of next-generation closed-loop or adaptive deep brain stimulation devices to read and write shows great potential to effectively manage movement, seizure, and psychiatric disorders, and also raises the possibility of using aDBS to electively modulate mood, cognition, and prosociality. What separates aDBS from most neurotechnologies currently used for enhancement is that aDBS remains an invasive, surgically-implanted technology with a risk-benefit ratio significantly different when applied to diseased versus non-diseased individuals. Despite a large discourse about the ethics of enhancement, (...) no empirical studies yet examine perspectives on enhancement from within the aDBS research community. We interviewed 23 aDBS researchers about their attitudes toward expanding aDBS use for enhancement. A thematic content analysis revealed that researchers share ethical concerns related to safety and security; enhancement as unnecessary, unnatural or aberrant; and fairness, equality, and distributive justice. Most researchers felt that enhancement applications for DBS will eventually be technically feasible and that attempts to develop such applications for DBS are already happening. However, researchers unanimously felt that DBS ideally should not be considered for enhancement until researchers better understand brain target localization and functioning. While many researchers acknowledged controversies highlighted by scholars and ethicists, such as potential impacts on personhood, authenticity, autonomy and privacy, their ethical concerns reflect considerations of both gravity and perceived near-term likelihood. (shrink)

As a continuation of the work of the third author in [5], we make further observations on the features of Galois cohomology in the general model theoretic context. We make explicit the connection between forms of definable groups and first cohomology sets with coefficients in a suitable automorphism group. We then use a method of twisting cohomology (inspired by Serre’s algebraic twisting) to describe arbitrary fibres in cohomology sequences—yielding a useful “finiteness” result on cohomology sets. Applied to the special case (...) of differential fields and Kolchin’s constrained cohomology, we complete results from [3] by proving that the first constrained cohomology set of a differential algebraic group over a bounded, differentially large, field is countable. (shrink)

El presente artículo es la primera traducción española de un artículo del jurista alemán Hermann Heller titulado "¿Liberalismo autoritario?", en el que pretende dar cuenta de una nueva forma de articulación política que se desarrolla al comienzo de los años 30 en Alemania y que combina el autoritarismo político con el liberalismo económico.

This paper aims to provide a philosophical and theoretical account of biological communication grounded in the notion of organisation. The organisational approach characterises living systems as organised in such a way that they are capable to self-produce and self-maintain while in constant interaction with the environment. To apply this theoretical framework to the study of biological communication, we focus on a specific approach, based on the notion of influence, according to which communication takes place when a signal emitted by a (...) sender triggers a change in the behaviour of the receiver that is functional for the sender itself. We critically analyse the current formulations of this account, that interpret what is functional for the sender in terms of evolutionary adaptations. Specifically, the adoption of this etiological functional framework may lead to the exclusion of several phenomena usually studied as instances of communication, and possibly even of entire fields of investigation such as synthetic biology. As an alternative, we reframe the influence approach in organisational terms, characterising functions in terms of contributions to the current organisation of a biological system. We develop a theoretical account of biological communication in which communicative functions are distinguished from other types of biological functions described by the organisational account (e.g. metabolic, ecological, etc.). The resulting organisational-influence approach allows to carry out causal analyses of current instances of phenomena of communication, without the need to provide etiological explanations. In such a way it makes it possible to understand in terms of communication those phenomena which realise interactive patterns typical of signalling interactions – and are usually studied as such in scientific practice – despite not being the result of evolutionary adaptations. Moreover, this approach provides operational tools to design and study communicative interactions in experimental fields such as synthetic biology. (shrink)

El artículo parte de un interrogante por el estatuto teórico-epistemológico de las condiciones de producción del discurso desde una perspectiva que combina el análisis materialista del discurso francés con la sociología de las problematizaciones. Propone tres modos de puesta en juego de las condiciones de producción, según el momento del proceso de investigación en que intervienen y el peso explicativo que revisten en el resultado: descriptivo, indiciario y estratégico. Establece la necesidad de dar cuenta de la multiplicidad de trayectorias, redes, (...) dispositivos y prácticas que conforman las condiciones de producción del discurso, lo que conduce a una nueva pregunta por modos de re-anudar lo disperso. Finalmente, propone la figura de la “nebulosa” como un modo de presentación y exploración de los datos que no sacrifique su constitutiva heterogeneidad. (shrink)

Patients with strokes to the Anterior Communicating Artery pose an important challenge to rehabilitation teams due to a particular mix of cognitive and behavioral impairments. These deficits often compromise engagement with rehabilitation, learning and generalization. The goal of this article is to describe the long-term presentation of a patient with an ACoA stroke as well as her rehabilitation needs and the many challenges experienced by the rehabilitation team when attempting to facilitate functional, vocational and psychosocial recovery. Based on this case, (...) and the existing literature, a neuropsychological rehabilitation framework to understand and address the specific problems and needs of this population is proposed. This framework demands rehabilitation teams to consider: the slow pattern of recovery of this population, the interaction between cognitive and behavioral impairments, the relevance of physical and social environments, the value of personal projects and the need to include psychological and relational interventions. (shrink)

Perner and Roessler Causing human action: new perspectives on the causal theory of action, MIT Press, Cambridge, MA, pp 199–228, 2010) hold that children who do not yet have an understanding of subjective perspectives, i.e., mental states, explain actions by appealing to objective facts. In this paper, we criticize this view. We argue that in order to understand objective facts, subjects need to understand perspectives. By analysing basic fact-expressing assertions, we show that subjects cannot refer to facts if they do (...) not understand two types of perspectivity, namely, spatial and doxastic perspectivity. To avoid conceptual confusion regarding different ways of referring to facts, we distinguish between reference to facts de re and de dicto. (shrink)

An account of assertion along truth-relativistic lines is offered. The main lines of relativism about truth are laid out and the problematic features that assertion acquires in the presence of relative truth are identified. These features are the possibility of coherently formulating norms of assertion and the possibility of grounding a rational practice of assertion upon relative truth. A solution to these problems is provided by formulating norms for making and assessing assertions that employ a suitably relativized truth predicate and (...) a perspectival notion of correctness. Two potential objections to this proposal are addressed. (shrink)

El trabajo tiene por objeto reflexionar críticamente sobre el retribucionismo como fin de la pena en el Estado constitucional de Derecho. Tomando como punto de partida el idealismo alemán, se analizan las reformulaciones más recientes de esta corriente de pensamiento aparentemente superada. Se propone una distinción metodológica entre los términos retribución, reprobación y venganza, en orden a la defensa de una teoría de la pena secularizada.

Vocal bursts are non-linguistic affectively-laden sounds with a crucial function in human communication, yet their affective structure is still debated. Studies showed that ratings of valence and arousal follow a V-shaped relationship in several kinds of stimuli: high arousal ratings are more likely to go on a par with very negative or very positive valence. Across two studies, we asked participants to listen to 1,008 vocal bursts and judge both how they felt when listening to the sound (i.e. core affect (...) condition), and how the speaker felt when producing it (i.e. perception of affective quality condition). We show that a V-shaped fit outperforms a linear model in explaining the valence-arousal relationship across conditions and studies, even after equating the number of exemplars across emotion categories. Also, although subjective experience can be significantly predicted using affective quality ratings, core affect scores are significantly lower in arousal, less extreme in valence, more variable between individuals, and less reproducible between studies. Nonetheless, stimuli rated with opposite valence between conditions range from 11% (study 1) to 17% (study 2). Lastly, we demonstrate that ambiguity in valence (i.e. high between-participants variability) explains violations of the V-shape and relates to higher arousal. (shrink)

This article critiques the theological and moral foundations that undergird the approach of the document For the Life of the World: Toward a Social Ethos of the Orthodox Church to the question of the Church's role in the public sphere. The article's focus is essentially two-fold. First, it strives to clarify For the Life of the World's hermeneutical method through a consideration of its frequent appeals to the authority of the Orthodox tradition. Second, the article seeks to understand the document's (...) tacit reliance upon a Eucharistic model of ecclesiology and its connection to the recurring theme of the ‘transfiguring of the world’. (shrink)

¿Dónde hallar al marxismo hoy? Contestar esta pregunta suscita el problema que Jacques Derrida (1995: 40) asume cuando sostiene: “hay más de uno, debe haber más de un (Marx)”. ¿Cuál es entonces el Marx que Althusser nos invita a leer y a llevar a la acción política? El objetivo de este texto es rastrear los lineamientos del Marx que sugiere Althusser (a través de los conceptos de práctica política y práctica teórica) en el pensamiento de Álvaro García Linera.Estos conceptos althusserianos (...) nos llevan a plantear a Álvaro García Linera como “heredero” (Derrida, 1995) de la filosofía marxista. Por su condición de militante y vicepresidente de Bolivia, su producción teórica se desarrolla dentro de una coyuntura muy particular. Es así como podemos entender que García Linera no hace más que abordar en su producción teórica un problema que está objetivamente planteado por el proceso en el que se encuentra: la potencia emancipadora del componente comunitario indígena.Pondremos el foco en la relectura del Manifiesto comunista que propone García Linera a través de estos conceptos althusserianos para adentrarnos en un pensamiento que invoca a Marx al mismo que tiempo que resalta la necesidad de pensar dentro de la coyuntura. De esta manera, no buscamos sacar conclusiones sobre su verdad o falsedad sino más bien producir un análisis político de su discurso con el fin de rastrear las contradicciones que surgen de leer a Marx a través de las variantes que propone la coyuntura, y así profundizar los análisis en comunicación y política.También nos valdremos de entrevistas, conferencias y otros escritos suyos para situar su pensamiento en la actualidad. Finalmente nos proponemos rastrear una serie de interlocutores con los que discute y argumenta para sentar las bases de un proyecto de investigación que profundice el análisis de su obra. (shrink)

Pensar el 2001, interpelar a las subjetividades de la crisis. Entrevista a Diego Sztulwark.

Neutral Counterpart Theories of slurs hold that the truth-conditional contribution of a slur is the same as the truth-conditional contribution of its neutral counterpart. In, DiFranco argues that these theories, even if plausible for single-word slurs like ‘kike’ and ‘nigger’, are not suitable for complex slurs such as ‘slanty-eyed’ and ‘curry muncher’, figurative slurs like ‘Jewish American Princess’, or iconic slurring expressions like ‘ching chong’. In this paper, we argue that these expressions do not amount to genuine counterexamples to neutral (...) counterpart theories of slurs. We provide a positive characterization of DiFranco's examples that doesn't deviate from the core of those theories. (shrink)

Introducción al dossier: “A 20 años del 2001: memorias, representaciones, militancias y reverberancias”.

La pobreza tiene una base material, la penuria de recursos. Pero su naturaleza es moral, consiste en el reconocimiento de que ciertas situaciones son acreedoras de acciones preventivas o remediadoras. Las sociedades vienen colocando tradicionalmente el umbral de pobreza en el punto por debajo del cual esta en peligro la subsistencia. Pero la conciencia reformista del mundo occidental ha llegado a servirse de la idea de pobreza para señalar los fallos de su compromiso de igualdad social. No se trata tanto (...) de una benévola elevación del baremo, como de una reconceptualización acorde con la ideología política dominante. (shrink)

The work is a philosophical essay that deals with the human condition - "subjugated to unprecedented levels of uncertainty" - and contemporary art as a form of knowledge. Author Ramiro Garavito is an art curator, artist, philosopher and promoter of contemporary art in Bolivia.

This paper presents a pilot study that explores instances of objectless awareness during sleep: conscious experiences had during sleep that prima facie lack an object of awareness. This state of objectless awareness during sleep has been widely described by Indian contemplative traditions and has been characterised as a state of consciousness-as-such; while in it, there is nothing to be aware of, one is _merely_ conscious (cf. Evans-Wentz, 1960 ; Fremantle, 2001 ; Ponlop, 2006 ). While this phenomenon has received different (...) names in the literature, such as ‘witnessing-sleep’ and ‘clear light sleep’ among others, the specific phenomenological profile of this state has not yet been rigorously studied. This paper aims at presenting a preliminary investigation of objectless consciousness during sleep using a novel tool in qualitative research that can guide future research. Five participants experiencing objectless consciousness during sleep were interviewed following the _Micro-phenomenological Interview_ technique (MPI; Petitmengin, 2005, 2006 ). All participants reported an experience they had during sleep in which there was no scenery and no dream. This period labelled as ‘No Scenery/Void’ was either preceded by the dissolution of a lucid dream or by other forms of conscious mentation. The analysis of the results advances four experiential dimensions during this state of void, namely (1) Perception of absence, (2) Self-perception, (3) Perception of emotions, and (4) Perception of awareness. While the results are primarily explorative, they refer to themes found in the literature to describe objectless sleep and point at potential avenues of research. The results from this study are taken as indications to guide future operationalisations of this phenomenon. (shrink)

El texto intenta mostrar los rasgos que señalan la vinculación de la obra cosmológica de Bruno con el acontecimiento histórico cultural denominado Revolución Copernicana, y se centra en una primera fase que documenta las relaciones entre infinitismo y astronomía copemicana. El horizonte de la argumentación lo constituye la intención de situar el pensamiento de Bruno entre las primeras aportaciones teóricas a la modernidad.

The aim of the paper is to evaluate the prospects for an aesthetically informed assessment-sensitive semantic account of thick aesthetic predicates (TAPs) such as 'intense', 'sombre', ‘balanced’, ‘harmonious’, etc. We distinguish two meaning dimensions concerning TAPs, truth-conditional and use-conditional or expressive, and provide a dualist semantics that posits assessment sensitivity at both levels. Then we evaluate the extent to which assessment sensitivity is an apt rendition of aesthetic discourse involving TAPs. We distinguish between experiential TAPs (‘intense’, ‘sombre’) and theoretical TAPs (...) (‘balanced’, ‘dynamic’), and argue that there is evidence for a relativistic construal both at the truth-conditional and the expressive level for experiential TAPs, but not for theoretical TAPs. Thus, an upper bound is found on how much assessment sensitivity characterises aesthetic discourse. (shrink)

Presento una extensión del marco de Stalnaker para modelar los efectos conversacionales de la aserción, de modo que este pueda aplicarse a la aserción de proposiciones cuya verdad es relativa a parámetros adicionales respecto de un mundo posible. Desarrollo dos maneras de aplicar este marco a la aserción de proposiciones evaluativas, según la apreciación de las emisiones evaluativas mismas refleje una concepción relativista moderada de sus condiciones de corrección o una concepción radical. Argumento que, en virtud de la diferencia que (...) existe a la hora de concebir la aserción, el relativismo radical tiene una ventaja por sobre el relativismo moderado, dado que el relativismo moderado tiene inconvenientes a la hora de interpretar los desacuerdos evaluativos. I present an extension of Stalnaker's framework for modeling the conversational effects of assertion, so that it may be applied to the assertion of propositions whose truth is relative to parameters beyond a possible world. I develop two ways in which the new framework may be applied to the assertion of evaluative propositions, depending on whether the assessment of evaluative utterances reflects a moderate or a radical conception of their correctness conditions. I argue that, in virtue of this difference in the conceptualization of assertion, radical relativism has an advantage over moderate relativism, for moderate relativism faces problems with respect to the interpretation of evaluative disagreement. (shrink)

Among the philosophical accounts of reference, Quine’s The Roots of Reference stands out in offering an integrated account of the acquisition of linguistic reference and object individuation. Based on a non-referential ability to distinguish bodies, the acquisition of sortals and quantification are crucial steps in learning to refer to objects. In this article, we critically re-assess Quine’s account of reference. Our critique will proceed in three steps with the aim of showing that Quine effectively presupposes what he sets out to (...) explain, namely, reference to objects. We are going to argue that sortals do not individuate, that bodies are already objects, and that the acquisition of variables presupposes a notion of identity. The result is diagnostic of a central desideratum for any theory of reference: an explanation of spatiotemporal object individuation. (shrink)